Volume 3, Number 2, pp. 50 - 53
A. Zedginidze,1,2 Kh. Gvimradze,1,2 M. Antelava,1,2 L. Shanshiashvili,2,3 D. Dzneladze,2,3 N. Zakariadze2 and D. Mikeladze3
1Georgian Institute of Haematology and Transfusiology,
Tbilisi, Georgia
2NGO “Biomedinfo”, Tbilisi, Georgia
3Institute of Physiology, Georgian Academy of Sciences, 14 Gotua
St, 380060 Tbilisi, Georgia
Correlation between acrocentric chromosome association
and the level of p53 in people exposed to low doses of radioactivity
The frequency of chromosome aberrations in circulating lymphocytes is accepted
as the most reliable indicator for absorbed dose of radiation. Cytogenetic
investigation was carried out on peripheral blood lymphocytes and the level
of serum p53 of military personnel from a former military base where sources
of radiation were found, and residents living in a village close to a military
base in areas contaminated with radionuclides. It was found that the index
of chromosome satellite association and the content of p53 were increased
only in residents of the village. There was a significant positive correlation
between the frequency of satellite associations and the level of p53. No correlation
between these variables was found among the temporary military staff
of the base. These data indicate that only long term chronic exposure to
low doses of radiation induces increased association of acrocentric chromosomes,
which is correlated with p53-dependent transcriptional activity.
Keywords:dicentric, low doses of radiation, p53, satellite association