2020
Volume 20, Number 1, pp. 27-31
Targeted delivery of quercetin-loaded magnetic nanoparticles inhibits kainate-induced epileptiform discharges
M. Kurasbediani, B. Chkhartishvili, M. Chikovani, B. Partsvania and N. Doreulee
Biology Department, Faculty of Exact and Natural Sciences, Ivane Javakishvili State University, Tbilisi, Georgia
Epilepsy is a progressive neurological disease characterized by recurrent seizures and behavioural comorbidities, and found in 1% of the world population. Development of epilepsy is associated with complex interaction of multiple factors. Despite more than 20 approved antiepileptic drugs, about 30% of patients are refractory to treatment. Considering the importance of oxidative stress in epilepsy disorders as well in glutamate-induced excitotoxicity damage, it has been suggested that antioxidant and antiinflammatory treatments may attenuate or prevent the neurodegenerative disorders connected with glutamate excitotoxicity. Among antioxidants, flavonoids of plant origin are of particular interest. One of the best-described plant flavonoids is quercetin. Application of quercetin in the pharmaceutical field is limited by its low absorption into the body based on its poor solubility, poor permeability, low bioavailability and instability. Nanoparticles can be used for the delivery of biologically active substances to various areas of the body; loading nanoparticles with drugs increases their stability and their targeted delivery. In the present work we have shown that imposition of an external static magnetic field to achieve the targeted delivery of quercetin-loaded magnetic nanoparticles to the brain causes significant depression of kainic acid-induced epileptiform activity in the hippocampus.
Keywords: epilepsy, quercetin, magnetic field, nanoparticles