2015
Volume 15, Number 1, pp. 9–11
Blood cell deformation after blood loss
M. Mantskava, N. Momtselidze and L. Davlianidze
I. Beritashvili Centre of Experimental Biomedicine, 14 Gotua St, 0160 Tbilisi, Georgia
This report describes red blood cell deformation (as a rheological marker) after different degrees of severity of experimental haemorrhagic shock. The modelling of haemorrhagic shock at different stages was carried out on a group of anaesthetized animals by means of standard blood discharge from the femoral artery (2.5 mL—the first stage of shock; 5 mL—the second stage of shock; 5 mL—the third stage of shock, n = 12). The results showed that the deformability index decreased with the progression of stages. In parallel with the study of the deformability of erythrocytes, rheological parameters were monitored with a view to the development of a procedure of intensive therapy and a diagnosis of massive blood loss, as well as of haemorrhagic shock.
Keywords:blood rheology, haemorrhagic shock, red blood cell (RBC) deformability