M. Leladze, E. Nozadze and Z. Kometiani
I. Beritashvili Institute of Physiology, Georgian Academy
of Sciences, 14, Gotua St., 380060 Tbilisi, Georgia
On the molecular mechanism of Na,K-ATPase isoforms
There exist data according to which the molecular mechanism of the Na,K-ATPase of kidney differs from that of Na,K-ATPase of brain in nonexistence of the Mg-dependent mode (free [Mg2+] >>[ATPfree] ). On the other hand, there are several isoforms in brain, but only one in kidney. As a result of investigating the influence of ouabain on Na,K-ATPase, it turned out the OPM mode is not engendered by the variety of a-isoforms, but may be dependent on b-isomerization.