Volume 8, Number 4, p.p. 151–154
Minireview HMGB1—a protein with dual function
L. Shanshiashvili,1,2 M. Shatirishvili,1 I. Kalandadze,2 and D. Mikeladze1,2
1
I. Chavchavadze State University, 0179 Tbilisi, Georgia
2
I. Beritashvili Institute of Physiology, 0160 Tbilisi, Georgia
HMGB1 was originally considered to be a nuclear protein and for a long time was studied for its intranuclear functions only, but during the last few years has been shown to have multiple extracellular functions, an overview of which is given.
Keywords:
DNA-binding protein, HMGB1, inflammation, nuclear cytokine