Volume 5, Number 2/3, pp. 111-113
On the mechanism of influence of the anticancer antibiotic adriablastin on DNA
M. Khvedelidze, T. Mdzinarashvili, G. Khelashvili, G. Gogoladze, A. Ivanova and G. Mrevlishvili
Tbilisi State University, 3 Chavchavadze Ave, 0128 Tbilisi, GeorgiaCalorimetric and viscometric investigation of the DNA-adriablastin complex has shown that interaction between adriablastin and DNA occurs. The calorimetric investigations show that a dramatic decrease of the specific enthalpy takes place upon adriablastin addition, which indicates the destruction of stacking between bases. The results of the viscometric investigations of the adriablastin-DNA complex imply that intercalation of adriablastin into the DNA structure occurs. This is evidenced by the increasing viscosity of the adriablastin-DNA complex. The experimental results obtained allow the possible mechanism of action of adriablastin as an anticarcinogenic drug to be suggested
Keywords: adriablastin, anticancer drug, calorimetry, DNA, viscometry