Volume 8, Number 1, p.p. 13–16
Rat brain creatine kinase and succinate dehydrogenase activity changes during chronic stress
M. Chipashvili, K. Menabde, N Zaalishvili, E. Juravliova and N. Koshoridze*
Department of Biology, I. Javakhishvili State University, 2 University St, 0128 Tbilisi, Georgia
In conditions of stress induced by a disordered day/night cycle and social isolation, alterations of the mitochondrial and cytoplasm isoforms of creatine kinase, and succinate dehydrogenase, have been studied in rats. We have found that the activities of these two enzymes changed more significantly in the brain hippocampus than in the cortex. These data indicate that during chronic stress in the brain hippocampus the rate of oxidative phosphorylation decreases and is accompanied by a significant diminution of energy-rich substances.
Keywords:
chronic stress, creatine kinase, phosphocreatine, succinate dehydrogenase